Located in the opposite direction (5)
I believe the answer is:
sited
'located' is the definition.
('site' can be a synonym of 'locate')
'in the opposite direction' is the wordplay.
'in' indicates the answer is hidden within the clue.
'SITED' can be found hidden inside 'opposite direction'.
(Other definitions for sited that I've seen before include "Placed, located" , "Put" , "Positioned" , "installed" , "Situated" .)