Loco, a flier? (6)
I believe the answer is:
cuckoo
I believe this clue is a double definition.
'loco' is the first definition.
'a flier?' is the second definition.
(cuckoo is a kind of birdanimal)
(Other definitions for cuckoo that I've seen before include "Bats" , "Crackpot bird?" , "building no nest?" , "Bananas" , "Out to lunch" .)