Lois running to the store (4)
I believe the answer is:
silo
'the store' is the definition.
(a store of crops)
'lois running' is the wordplay.
'running' indicates anagramming the letters (the letters run around to different places).
'lois' is an anagram of 'SILO'.
'to' is the link.
(Other definitions for silo that I've seen before include "Grain store; missile site" , "Farm store; soil (anag.)" , "Tower used for storing fodder" , "Farm grain storer" , "Underground chamber for a missile" .)