London area of note with nothing (4)
I believe the answer is:
soho
'london area' is the definition.
(I've seen this before)
'note with nothing' is the wordplay.
'note' becomes 'soh' (I've seen this before**).
'with nothing' becomes 'o' (I've seen this in other clues).
'soh'+'o'='SOHO'
'of' is the link.
(Other definitions for soho that I've seen before include "(Formerly) disreputable area of London" , "Colourful district in central London" , "Huntsman's call - area of London" , "Colourful London show-biz district" , "Smoke's part" .)