Loner depressed about dweeb (4)
I believe the answer is:
nerd
'dweeb' is the definition.
(I know that dweeb can be written as nerd)
'loner depressed about' is the wordplay.
'about' indicates a hidden word (the clue goes around or about the answer).
'NERD' is hidden in the letters of 'loner depressed'.
(Other definitions for nerd that I've seen before include "Anorak (informal)" , "Technical expert" , "Socially inept but knowledgeable person" , "Sort of chap" , "Studious bore" .)