Long to take one round the hotel (4)
I believe the answer is:
ache
'long to' is the definition.
(thesaurus)
'one round the hotel' is the wordplay.
'one' becomes 'ace' (synonyms).
'round' means one lot of letters goes inside another.
'the hotel' becomes 'h' (phonetic alphabet: alpha, bravo, charlie etc.).
'ace' placed around 'h' is 'ACHE'.
'take' is the link.
(Other definitions for ache that I've seen before include "anguish" , "Dull continuous pain" , "Persistent dull pain" , "Cause pain" , "yearning" .)