Look after Scamp and spoil (6)
I believe the answer is:
impair
'spoil' is the definition.
('impair' can be a synonym of 'spoil')
'look after scamp' is the wordplay.
'look' becomes 'air' (I've seen this before).
'after' means one lot of letters go next to another.
'scamp' becomes 'imp' ('imp' can be a synonym of 'scamp').
'air' after 'imp' is 'IMPAIR'.
'and' is the link.
(Other definitions for impair that I've seen before include "Hobble" , "Cause weakening of, damage" , "Hinder" , "Courteous man (colloq.)" , "'Mar, spoil (6)'" .)