Look to secure universal thin fabric (5)
I believe the answer is:
gauze
'thin fabric' is the definition.
(I've seen this before)
'look to secure universal' is the wordplay.
'look' becomes 'gaze' (gaze is a kind of look**).
'to secure' means one lot of letters goes inside another.
'universal' becomes 'u'.
'gaze' placed around 'u' is 'GAUZE'.
(Other definitions for gauze that I've seen before include "Medical dressing" , "Thin bleached cotton cloth used for dressings etc" , "Medical cloth" , "first-aid material" , "Bandage material" .)