Looked up "profound" again in it (6)
I believe the answer is:
peered
'looked' is the definition.
(peering is a kind of looking)
'up profound again in it' is the wordplay.
'up' says the letters should be written backwards (in down clue: letters go upwards).
'profound' becomes 'deep' (synonyms).
'again' becomes 're' (prefix meaning 'again').
'in it' is an insertion indicator.
'deep' going around 're' is 'dereep'.
'dereep' reversed gives 'PEERED'.
(Other definitions for peered that I've seen before include "Looked searchingly" , "Having been made a Lord < examined" , "Look searchingly" , "Looked closely" , "Looked through narrowed eyes" .)