Looked up to say more about Slough (7)
I believe the answer is:
admired
'looked up to' is the definition.
(I've seen this before)
'say more about slough' is the wordplay.
'say more' becomes 'add' (I've seen this before).
'about' is an insertion indicator.
'slough' becomes 'mire' (I am not sure about this - if you are sure you should believe this answer much more).
'add' going around 'mire' is 'ADMIRED'.
Can you help me to learn more?
(Other definitions for admired that I've seen before include "I'd dream (anag.)" , "Cherished" , "Had a high opinion of" , "Popular" , "Esteemed" .)