Loose Independent clue is not to be beaten (10)
I believe the answer is:
licentious
'loose' is the definition.
('licentious' can be a synonym of 'loose')
'independent clue is not to be beaten' is the wordplay.
'independent' becomes 'i'.
'to be beaten' indicates an anagram.
'i'+'clue'+'is'+'not'='iclueisnot'
'iclueisnot' with letters rearranged gives 'LICENTIOUS'.
(Other definitions for licentious that I've seen before include "disregarding accepted rules" , "Depraved" , "Abandoned" , "Promiscuous" .)