Loose nuts screwed up, then hit (7)
I believe the answer is:
unstrap
'loose' is the definition.
(thesaurus)
'nuts screwed up then hit' is the wordplay.
'screwed up' is an anagram indicator.
'then' says to put letters next to each other.
'hit' becomes 'rap' (I've seen this in other clues**).
'nuts' is an anagram of 'unst'.
'unst'+'rap'='UNSTRAP'
(Other definitions for unstrap that I've seen before include "Loosen tie" , "Remove fastenings from" , "loose" , "Release" .)