Loosen with sire liable to change (10)
I believe the answer is:
liberalise
'change' is the definition.
(I know that liberalise is a type of change)
'loosen with sire liable' is the wordplay.
'loosen' is an anagram indicator.
'with' is a charade indicator (letters next to each other).
'sire' next to 'liable' is 'sireliable'.
'sireliable' with letters rearranged gives 'LIBERALISE'.
'to' is the link.
(Other definitions for liberalise that I've seen before include "make more free!" , "Enlighten" .)