Looted overthrown city (6)
I believe the answer is:
toledo
'city' is the definition.
(Toledo is a Spanish city)
'looted overthrown' is the wordplay.
'overthrown' indicates an anagram.
'looted' is an anagram of 'TOLEDO'.
(Other definitions for toledo that I've seen before include "historic Spanish city" , "Spanish city noted for swords" , "Span. sword-making city" , "Looted (anag) - Spanish city" , "Blade" .)