Lord, he's no end of trouble! (5)
I believe the answer is:
noble
'lord' is the definition.
(I know that lord can be written as noble)
'he's no end of trouble' is the wordplay.
'he' becomes 'Noe'.
'no end' means to remove the last letter.
'of trouble' becomes 'ble' (I can't justify this - if you can you should give a lot more credence to this answer).
'noe' with its last letter taken away is 'no'.
'no'+'ble'='NOBLE'
Can you help me to learn more?
(Other definitions for noble that I've seen before include "Maybe count" , "with a title?" , "Worthy" , "Having high moral qualities" , "Imposing, magnificent" .)