Lose hope as pride's hurt (7)
I believe the answer is:
despair
'lose hope' is the definition.
(synonyms)
'as pride's hurt' is the wordplay.
'hurt' indicates an anagram.
'as'+'pride'='aspride'
'aspride' anagrammed gives 'DESPAIR'.
(Other definitions for despair that I've seen before include "Complete absence of hope" , "State of having lost all hope" , "sort of counsel?" , "Complete loss of hope" , "Despondency" .)