Lose hope (7)
'lose hope' is the definition.
(synonyms)
This is all the clue.
(Other definitions for despair that I've seen before include "Be without hope" , "Give up hope" , "Lose heart" , "Resignation" , "Praised (anag) - lose hope" .)
'lose hope' is the definition.
(thesaurus)
This is all the clue.
(Other definitions for despond that I've seen before include "Its Slough, Bunyan" , "Become disheartened" .)