Lose it, following cheeky comments (4)
I believe the answer is:
flip
'lose it' is the definition.
(both can mean to become very angry suddenly)
'following cheeky comments' is the wordplay.
'following' becomes 'f' (used when citing page numbers etc).
'cheeky comments' becomes 'lip' (lip can mean insolent remarks from a person).
'f'+'lip'='FLIP'
(Other definitions for flip that I've seen before include "hit the roof" , "Turn quickly over; sort of chart" , "Turn (over) - impudent" , "Suddenly go berserk" , "Lose one's cool - reverse side" .)