Lose it wildly over a key to remote (8)
I believe the answer is:
isolated
'remote' is the definition.
(I've seen this before)
'lose it wildly over a key' is the wordplay.
'wildly' is an anagram indicator.
'over' means one lot of letters goes inside another.
'key' becomes 'd' (I've seen this in other clues**).
'lose'+'it'='loseit'
'loseit' is an anagram of 'isolte'.
'isolte' enclosing 'a' is 'isolate'.
'isolate'+'d'='ISOLATED'
'to' acts as a link.
(Other definitions for isolated that I've seen before include "Off the beaten track" , "Single" , "kept apart from others" , "Cut off or left behind" , "Placed alone" .)