Lose job in area away from cheap ghetto in trouble (3,3,4)
I believe the answer is:
get the chop
'lose job' is the definition.
(I've seen this before)
'area away from cheap ghetto in trouble' is the wordplay.
'area' becomes 'a' (maths abbreviation).
'away from' suggests deleting specific letters.
'in trouble' indicates anagramming the letters.
'cheap'+'ghetto'='cheapghetto'
'cheapghetto' with 'a' removed is 'chepghetto'.
'chepghetto' with letters rearranged gives 'GET THE CHOP'.
'in' acts as a link.
(Other definitions for get the chop that I've seen before include "bring home the bacon?" , "Be sacked" , "Secure one for grilling" , "Visit the butcher to do so?" , "Sack" .)