Lose Minehead's first couple's home (8)
I believe the answer is:
misplace
'lose' is the definition.
(to misplace something is to lose it)
'minehead's first couple's home' is the wordplay.
'minehead' becomes 'm' (head letter of 'mine').
'first couple's' becomes 'is' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
'home' becomes 'place' (synonyms).
'm'+'is'+'place'='MISPLACE'
Can you help me to learn more?
(Other definitions for misplace that I've seen before include "Lose temporarily - put in wrong location" , "Mislay" , "Do bad filing" , "Lose - limp case (anag)" , "Set in the wrong position" .)