Loss of silver accepted by lady (6)
I believe the answer is:
damage
'loss' is the definition.
(damage is a kind of loss)
'silver accepted by lady' is the wordplay.
'silver' becomes 'ag' (Ag is the chemical symbol for silver).
'accepted by' indicates putting letters inside.
'lady' becomes 'dame' ('dame' can be a synonym of 'lady'**).
'ag' inserted into 'dame' is 'DAMAGE'.
'of' acts as a link.
(Other definitions for damage that I've seen before include "Harm, impair" , "To vandalise" , "'Deface, impair (6)'" , "destruction" , "Deface, harm" .)