Lost top in drunken gamble (5)
I believe the answer is:
lotto
'gamble' is the definition.
(I've seen this before)
'lost top in drunken' is the wordplay.
'top' indicates taking the first letters (in a down clue, the first letter is top).
'in drunken' becomes 'otto' (I can't justify this - if you can you should believe this answer much more).
The initial letter of 'lost' is 'l'.
'l'+'otto'='LOTTO'
Can you help me to learn more?
(Other definitions for lotto that I've seen before include "chancy business" , "Children's game similar to bingo" , "National gambling game" , "Prize draw" , "National game with large money prizes" .)