Lots in trouble often have it removed (6)
I believe the answer is:
tonsil
'often have it removed' is the definition.
I can't tell whether this definition defines the answer.
'lots in trouble' is the wordplay.
'trouble' is an anagram indicator.
'lots'+'in'='lotsin'
'lotsin' anagrammed gives 'TONSIL'.
Can you help me to learn more?
(Other definitions for tonsil that I've seen before include "One of a pair in the throat" , "organ" , "One of two pieces of tissue in the throat" , "One often removed" , "No slit at the base of the tongue" .)