Loud noise overwhelms disheartened tenant at lowest point (6)
I believe the answer is:
bottom
'lowest point' is the definition.
(I've seen this before)
'loud noise overwhelms disheartened tenant' is the wordplay.
'loud noise' becomes 'boom' (I've seen this before).
'overwhelms' indicates putting letters inside.
'disheartened' suggests removing the centre (the middle or heart is removed).
'tenant' with its middle removed is 'tt'.
'boom' placed around 'tt' is 'BOTTOM'.
'at' acts as a link.
(Other definitions for bottom that I've seen before include "dry bed" , "Low point" , "Last" , "MND weaver" , "Lowest part or underside" .)