Loudly sets off with crews having cool talent for trading (12)
I believe the answer is:
salesmanship
'talent for trading' is the definition.
(being a salesman or trader)
'loudly sets off with crews having cool' is the wordplay.
'loudly' shows a homophone (sound like) (when spoken - not silently).
'sets off' becomes 'sails' (sails away).
'with' says to put letters next to each other.
'crews' becomes 'mans' (man can mean to crew or operate).
'having cool' becomes 'hip' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
'sails' sounds like 'sales'.
'sales'+'mans'+'hip'='SALESMANSHIP'
Can you help me to learn more?
(Another definition for salesmanship that I've seen is " Talent for shifting".)