Love in Macbeth represented great sacrifice (8)
I believe the answer is:
hecatomb
'great sacrifice' is the definition.
(I've seen this before)
'love in macbeth represented' is the wordplay.
'love' becomes 'o' (love means zero in tennis).
'in' is an insertion indicator.
'represented' is an anagram indicator.
'macbeth' anagrammed gives 'hecatmb'.
'o' placed within 'hecatmb' is 'HECATOMB'.
(Other definitions for hecatomb that I've seen before include "Large-scale sacrifice" , "mass slaughter" , "sacrifice victims" , "major sacrifice" , "Great quantity of victims" .)