Lover, once having pried, turned and ran out (7)
I believe the answer is:
expired
'ran out' is the definition.
('expire' can be a synonym of 'run out')
'lover once having pried turned' is the wordplay.
'lover once' becomes 'ex' (an ex-lover).
'having' says to put letters next to each other.
'turned' is an anagram indicator.
'pried' with letters rearranged gives 'pired'.
'ex'+'pired'='EXPIRED'
'and' is the link.
(Other definitions for expired that I've seen before include "Run out" , "Ran out or died" , "Lapsed" , "Came to an end" , "Died; elapsed" .)