Low-down royal regularly in Italy (5)
I believe the answer is:
genoa
'in italy' is the definition.
('Genoa' is part of 'italy')
'low-down royal regularly' is the wordplay.
'low down' becomes 'gen' (both can mean information).
'regularly' means one should take alternating letters (regularly take one letter, leave next etc.).
The alternating letters of 'royal' are 'oa'.
'gen'+'oa'='GENOA'
(Other definitions for genoa that I've seen before include "Italian city has no age, oddly" , "Cake type; foresail" , "Type of rich fruit cake" , "Seaport in northwestern Italy" , "North Italian port" .)