Low spirits of a cavity (10)
I believe the answer is:
depression
I believe this clue is a double definition.
'low spirits' is the first definition.
(thesaurus)
'a cavity' is the second definition.
(thesaurus)
'of' acts as a link.
(Other definitions for depression that I've seen before include "Pit" , "Nineteen twenty nine financial slump" , "valley" , "Bad times" , "mental anguish" .)