Luxurious hotel removed sign of the cross? (4)
I believe the answer is:
plus
'sign of the cross?' is the definition.
(a plus is a cross)
'luxurious hotel removed' is the wordplay.
'luxurious' becomes 'plush' (I've seen this before).
'hotel' becomes 'h' (phonetic alphabet: alpha, bravo, charlie etc.).
'removed' suggests deleting specific letters.
'plush' with 'h' taken away is 'PLUS'.
(Other definitions for plus that I've seen before include "Additional" , "Add" , "An advantage; positive" , "Positive and not a negative" , "Added extra" .)