Luxurious, large American hotel (4)
I believe the answer is:
lush
'luxurious' is the definition.
(I know that luxurious can be written as lush)
'large american hotel' is the wordplay.
'large' becomes 'L' (eg in clothes sizes).
'american' becomes 'US' (United States).
'hotel' becomes 'h' (phonetic alphabet).
'l'+'us'+'h'='LUSH'
(Other definitions for lush that I've seen before include "Lavish - boozer" , "Prolific" , "one wants a lot to drink" , "Abounding in lavish growth - alcoholic" , "Of grass, growing thickly and strongly" .)