Mad reason for moving from place to place (10)
I believe the answer is:
locomotive
'for moving from place to place' is the definition.
(I've seen this before)
'mad reason' is the wordplay.
'mad' becomes 'loco' (I've seen this in another clue).
'reason' becomes 'motive' (I've seen this in another clue).
'loco'+'motive'='LOCOMOTIVE'
(Other definitions for locomotive that I've seen before include "for moving from place to place" , "Rocket, perhaps" , "Able to move by oneself" , "Railway engine" , "one's attached to the train" .)