Mad supremo, the creator of Man (10)
I believe the answer is:
prometheus
'creator of man' is the definition.
The definition and answer can be both people as well as being singular nouns.
Perhaps they are linked in a way I don't understand?
'mad supremo the' is the wordplay.
'mad' indicates an anagram.
'supremo'+'the'='supremothe'
'supremothe' with letters rearranged gives 'PROMETHEUS'.
Can you help me to learn more?
(Other definitions for prometheus that I've seen before include "Prominent Greek" , "He was bound" , "Greek god" , "Gk. hero, gave men fire" , "-- Unbound (Shelley)" .)