Made a home with Ines -- I ignored Edward (6)
I believe the answer is:
nested
'made a home' is the definition.
(I've seen this before)
'ines i ignored edward' is the wordplay.
'ignored' is a deletion indicator.
'edward' becomes 'ted'.
'ines' with 'i' taken out is 'nes'.
'nes'+'ted'='NESTED'
'with' is the link.
(Other definitions for nested that I've seen before include "Built a home" , "Of bird, settled in to home" , "Settled in cosily like bird" , "Settled in comfortably, snuggled up" , "Settle in comfortably like a bird" .)