Crossword Genius

Made mad excursion, when put off by everyone (6,2,3,4)

Ross

I believe the answer is:

driven up the wall

'made mad' is the definition.
(to drive someone up the wall is to make them mad)

'excursion when put off by everyone' is the wordplay.
'excursion' becomes 'drive'.
'off' is an anagram indicator.
'by' means one lot of letters go next to another.
'everyone' becomes 'all' (I've seen this before).
'when'+'put'='whenput'
'whenput' with letters rearranged gives 'nupthew'.
'drive'+'nupthew'+'all'='DRIVEN UP THE WALL'

I've seen this clue in The Guardian.
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