Crossword Genius

Magnum ___ (masterpiece) (4)

Ross

I believe the answer is:

opus

(Other definitions for opus that I've seen before include "Musical composition in the soup" , "Musical piece" , "Work of 25 perhaps" , "Piece of music (with number)" , "Work (mus.)" .)

I've seen this clue in the Universal, The New York Times, the LA Times and the USA Today.
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