Maiden voyage by small destroyer leaving America (5)

I believe the answer is:

virgo

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'maiden' is the definition.
(I've seen this before)

I can't explain the remainder of the clue.

(Other definitions for virgo that I've seen before include "Sixth sign of zodiac" , "Star sign" , "Large constellation -- sign of the zodiac" , "Large constellation between Leo and Libra" , "number of stars" .)

I've seen this clue in The Guardian.

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