Main artery (5)

I think it could be either:

Which length description are you looking for?:

5,4

aorta

'main artery' is the definition.
(largest artery)

This is the entire clue.

(Other definitions for aorta that I've seen before include "This carries blood from the heart" , "Bloody channel" , "Main artery of body" , "A rota (anag)" , "Great artery in body" .)

I've seen this clue in the LA Times, the Sydney Morning Herald, The New York Times, the King Feature Syndicate, The Star Tribune, The Independent, The Telegraph, The Times, the USA Today, The Sun and The Mirror.

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