Main road with some reversing tyre tracks (6)
I believe the answer is:
artery
'main road' is the definition.
'some reversing tyre tracks' is the wordplay.
'reversing' is a reversal indicator.
'some' indicates the answer is hidden within the clue (some of the parts of the word are used).
'yretra' is hidden within 'tyre tracks'.
'yretra' reversed gives 'ARTERY'.
'with' acts as a link.
(Other definitions for artery that I've seen before include "main line" , "bloody path" , "Important transport route" , "Blood vessel; important route" , "vessel carrying vital supply" .)