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Major artery (5)

Ross

I think it could be either:

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7

aorta

'major artery' is the definition.
(I've seen this before)

This is all the clue.

(Other definitions for aorta that I've seen before include "Main artery from heart" , "Large blood-vessel" , "Principal artery" , "Bloody channel" , "Main artery of body" .)

I've seen this clue in The Star Tribune, the LA Times, The Mirror, the Sydney Morning Herald, the Universal, the Evening Standard, the King Feature Syndicate, The Telegraph, the USA Today, the Penny Press and The New York Times.
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