Major industrial region of north-west Germany (4)
I believe the answer is:
ruhr
'major industrial region of north-west germany' is the definition.
(I've seen this before)
This is all the clue.
(Other definitions for ruhr that I've seen before include "German industrial zone, river" , "German industrial region" , "Ger. industrial region" , "industrial valley" , "Traditional region of German heavy industry" .)