Make a fuss about heart of hurt animal (8)
I believe the answer is:
creature
'animal' is the definition.
('creature' can be a synonym of 'animal')
'make a fuss about heart of hurt' is the wordplay.
'make a fuss' becomes 'create' (I've seen this before).
'about' is an insertion indicator.
'heart of' means to look at the middle letters.
The centre of 'hurt' is 'ur'.
'create' placed around 'ur' is 'CREATURE'.
(Other definitions for creature that I've seen before include "These comforts make life easy" , "Bird, beast, insect etc" , "Brute" , "Living being" , "Animal or person" .)