Crossword Genius

Make a supreme effort (informal) (4,1,3)

Ross

I believe the answer is:

bust a gut

(Other definitions for bust a gut that I've seen before include "Give it everything" , "meet qualification for intestinal surgery?" , "Really work extra hard" , "Make a strenuous effort" , "Work extra hard to achieve something" .)

I've seen this clue in The Guardian.
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