Make amends with a tincture (5)
I believe the answer is:
atone
'make amends' is the definition.
'with a tincture' is the wordplay.
'with' is a charade indicator (letters next to each other).
'tincture' becomes 'tone' ('tone' can be a synonym of 'tincture').
'a' put next to 'tone' is 'ATONE'.
(Other definitions for atone that I've seen before include "Make reparation for a misdeed" , "remedy" , "Turn away from sin and do penance" , "Make good" , "Expiate" .)