Make drunk brew a beer in it (9)
I believe the answer is:
inebriate
'make drunk' is the definition.
('inebriate' can be a synonym of 'make drunk')
'brew a beer in it' is the wordplay.
'brew' indicates an anagram.
'a'+'beer'+'in'+'it'='abeerinit'
'abeerinit' is an anagram of 'INEBRIATE'.
(Other definitions for inebriate that I've seen before include "Drunkard" , "He's drunk" , "Get drunk" , "Intoxicate" , "drunken state" .)