Make mad by exploding grenade (7)
I believe the answer is:
derange
'make mad' is the definition.
(I've seen this before)
'exploding grenade' is the wordplay.
'exploding' is an anagram indicator.
'grenade' anagrammed gives 'DERANGE'.
'by' acts as a link.
(Other definitions for derange that I've seen before include "Make insane" , "cause confusion" , "Drive mad" , "Remove from order" , "Madden" .)