Make the acquaintance of and be full of, on return (4)
I believe the answer is:
meet
'make the acquaintance of' is the definition.
(I've seen this in another clue)
'be full of on return' is the wordplay.
'be full' becomes 'teem' (I've seen this in another clue).
'of on return' shows that the letters should be reversed in order (I've seen 'on return' mean this).
'teem' backwards is 'MEET'.
'and' is the link.
(Other definitions for meet that I've seen before include "Sporting encounter" , "Come together or run into" , "acceptable" , "See 24" , "Confront" .)