Make toxic men upset, prodded by very revolutionary individual (7)
I believe the answer is:
envenom
'make toxic' is the definition.
(I've seen this in another clue)
'men upset prodded by very revolutionary individual' is the wordplay.
'upset' is an anagram indicator.
'prodded by' means one lot of letters goes inside another (inserted letters prod their way into others).
'very' becomes 'v' (common abbreviation).
'revolutionary' says the letters should be written backwards (letters revolve around).
'individual' becomes 'one' (an individual is one person).
'one' written backwards gives 'eno'.
'men' with letters rearranged gives 'enm'.
'v'+'eno'='veno'
'enm' enclosing 'veno' is 'ENVENOM'.
(Another definition for envenom that I've seen is " Put poison on (archaic)".)