Make wealthy leaders of English nobility remain in city homes (6)
I believe the answer is:
enrich
'make wealthy' is the definition.
(to enrich someone is to make them wealthy)
'leaders of english nobility remain in city homes' is the wordplay.
'leaders of' suggests taking the first letters.
The initial letters of 'english nobility remain in city homes' is 'ENRICH'.
(Other definitions for enrich that I've seen before include "Give money" , "increase wealth" , "Add to and improve" , "Make wealthy or improve the quality" , "develop" .)